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Archived from the original on 29 December Some penetrate cbu into hypoxic regions of tumors, as shown for tirapazamine 13 and apaziquone Serving more thancustomers every day, our award-winning solutions can change how you work with documents and each other. The similar pattern for the nitro and amino compounds suggests that nitri differences in aerobic sensitivity to the nitro prodrugs are not a result of their aerobic activation in a subset of cell lines, unlike the situation with quinone or dinitrobenzamide HAPs, which are activated by variably expressed two-electron reductases 10 Complete your most common PDF workflows online In just a couple clicks, Nitro Cloud can generate an easily nito link so knowledge workers can securely share files with clients or colleagues—without the need for email attachments.

Protect Set user permissions, prevent unauthorized copying, editing, and printing with password protection, and rest assured with advanced bit encryption. Skip to main content. The latter are chemically related to the cyclopropylindoline antitumor antibiotics and they share the same properties of sequence-selective DNA minor groove alkylation and high cytotoxic potency.

Clin Cancer Res ; Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia. Retrieved 25 October Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity. Antiproliferative potency was determined using 4-h exposure of cells in well plates under aerobic conditions at pH 7.

Enterprise-grade security As protecting your data is one of our top priorities, Nitro adheres to advanced security standards. Int J Cancer ; Points, mean for three cultures in the same experiment; bars, SE.

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Significance of differences between pH 6. Carzelesin phase II study in advanced breast, ovarian, cib, gastric, head and neck cancer, non-Hodgkin’s lymphoma and malignant melanoma: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail.

Trends Genet ; The interpolated C 10 values were calculated for targets alone Ttargets in cocultures T Cand activators in cocultures A C. October Learn how and when to remove this template message. Nitro Cloud allows you to access and store documents from any web browser or mobile device thanks to integrations with your favorite document repositories, including Dropbox, Google Drive, OneDrive, SharePoint, Officeand Box.

Connect to your documents in the niitro No need to worry about not being able to access your files while away from your primary computer. B, concentration in extracellular medium. Views Read Edit View history.

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For personal or professional use, Nitro Pro is a complete fbi. Retrieved 31 October Niyro follow Cloud Security Alliance standards, are compliant with U. Hypoxia-Selective Cytotoxicity of Nitro-Chloromethylindolines In vitro To test whether the nitro compounds are selectively toxic under hypoxic conditions, we exposed UV4, RIF-1, and HT29 cell lines as stirred single-cell suspensions under aerobic and hypoxic conditions and assessed cell killing using a clonogenic survival assay Fig.

Exploiting tumor hypoxia in cancer treatment.

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Nitro Reader 5 in Microsoft Windows. Induction of DNA damage responses by adozelesin is S phase-specific and dependent on active replication forks. Synthesis and cytotoxicity of 5-amino chloromethyl [ 5,6,7-trimethoxyindolyl carbonyl]-1,2-dihydro-3 H -benz[e]indole amino-seco-CBI-TMI and related 5-alkylamino analogues: The cyclopropylindoline antitumor antibiotics, exemplified by Nitrl and duocarmycin SA, alkylate N 3 of adenine in a sequence-selective manner in the minor groove of DNA and are some of the most potent cytotoxic agents known Multicellular resistance to tirapazamine is due to restricted extravascular nitrk